Vengeance of the Chicken (2001)

After his brother ends up dead due to an assassin's misfire, the Chicken - yes, an actual chicken - decides to shoot the killer's brother as an act of revenge. The player's goal is to get the Chicken's mission to a successful, bloody end.

The game is controlled with a mouse; similarly to Sam & Max Hit The Road, right-clicking changes the cursor action (Walk to, Look at, Interact with, Talk to), while moving the cursor to the top of the screen makes a menu appear, allowing you to easily change the cursor actions, access one's inventory or save/load/quit the game.