In 2006, three years after the events of The House of the Dead 4, Kate Green joins forces with Ryan Taylor, the brother of her late partner and mentor, James, on an undercover mission in a dinner event within Scarecrow Manor, located in the outskirts of an unnamed U.S. state. The manager unleashes his army of mutant creatures upon the dinner guests. Realizing the threat to the world, Kate and Ryan then begin their quest to stop the manager and the outbreak he started.
As they progress through the mansion, they find clues related to the personnel of the DBR Corporation; Dr. Roy Curien, Caleb Goldman, and a mysterious man which Kate identifies as Thornheart, a descendant of the corporation's founding members, as well as the manager of Scarecrow Manor. Also during their exploration of the mansion, they fight gigantic mutants, such as resurrected creatures from the 1998 Curien Mansion incident, Chariot and Hangedman, as well as a new squid-like creature called the Priestess.развернуть