The game begins as the turtles watch a television newscast of April O'Neil reporting from Liberty Island. Suddenly, Krang flies in using his giant exosuit and steals the Statue of Liberty. Immediately thereafter Shredder hijacks the airwaves to laugh at the turtles. They head to downtown New York and pursue the Foot Clan through the streets and the city sewers, where Shredder sends them through a time warp. The turtles then have to fight Shredder's army through multiple eras of time to defeat him.