At the start of the game, Spider-Man finds a group of thugs attacking a woman. He fights them off, only to have the woman he saved call him a freak and run away. Spider-Man is then seen chasing Sandman through New York City. They engage in combat and Sandman is defeated, just before Rhino throws a car at Spider-Man, who avoids it. Rhino manages to escape and then the Triskelion can be seen in flames. It is later revealed that the fire was caused by an explosion, which let all super-villains free from the prison, along with symbiotes created from a mixture of the venom suit and OZ formula. Throughout the game, Spider-Man has to fight several villains which appear in Ultimate Spider-Man comics, such as Electro, Green Goblin and Rhino. Many of the villains' followers have to be fought as well, like symbiotes, thugs and goblins.
After fighting Electro, the police talks to Spider-Man, saying that if he keeps fighting villains, they would have to send Roxxon security robots to g...
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