As in the cooperative board game, the players take on the roles of 3-5 heroes who have teamed up to fight a single villain whose goals range from world domination to total annihilation. Each character is represented by their deck of specialized cards, which provide the means for interacting with the world and other characters. Complicating things is the environment deck, which adds additional effects or third parties onto the battlefield. The game can be played solo or multiplayer (either local or online across platforms). The base game contains the 10 heroes, 4 villains, and 4 environments from the Sentinels of the Multiverse basic set. Variant versions of some heroes and villains are unlockable bonus content. 6 additional heroes, 10 additional villains, and 6 additional environments are available as DLC and the publisher plans to eventually add all of the content from the physical game's expansions to the digital game.