The story is set two years after the "Leafmore Incident" (the events of the first Obscure); The Leafmore incident has been somehow covered-up. Shannon and Kenny are now enrolled in the nearby Fallcreek University, while Stan is reforming his life as a delivery truck driver. Stan and Kenny have to take medication to prevent the effects of the plant from infecting their bodies, while Shannon has been able to adapt to the changes.
As the story begins, a new drug created from a strange flower is quickly spreading its influence over the University's populace. Soon enough, a small group of students, along with the Leafmore High survivors have to face a horde of mutants and try to stay alive.
The spores spread through the whole city and later the whole country. The outbreak starts in a fraternity party of the ΔΘГ brotherhood. Amy and Kenny are the first ones to arrive, only to find the place infected when they get inside. The students then meet a scientist, Richard J...
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