The game is a spin-off from Chaos;Child, set in October 2015 in Shibuya, Tokyo. Bizarre events referred to as the "Reincarnation of the New Generation of Madness" take place, but do not interest the protagonist Miyashiro Takuru, the president of the school newspaper club; instead, he wants to focus on "real-life activities" and spending time with girls.
In Love Chu Chu!! the story is affected by player choices: by regularly uses the "Yes/No Trigger" system, in which they fill in "yes/no" questionnaires in the in-game magazine Cool Cat Press, which causes the story to branch depending on the player's answers.